The San Francisco 49ers are facing significant injury challenges as they prepare for their playoff clash against the Philadelphia Eagles. Key players, including left tackle Trent Williams and wide receiver Ricky Pearsall, are listed as questionable for the matchup. Williams has expressed confidence in his ability to play, though he is a game-time decision due to a hamstring issue. Pearsall, meanwhile, has not practiced recently due to knee and ankle problems. This injury report raises concerns as the 49ers have several starters also questionable, prompting discussions about potential roster moves. As the team navigates these challenges, the outcome of this crucial wild-card game may hinge on the availability of these key players.