A major winter storm is wreaking havoc on Thanksgiving travel plans for millions of Americans, with nearly 46 million people under winter weather alerts. Significant lake-effect snow is impacting regions like Northeast Ohio and the Great Lakes area, creating dangerous conditions for travelers. Meteorologists predict heavy snow and icy roads, particularly in the Midwest and North, where blizzard warnings have been issued. As travelers brace for tumultuous weather, flight delays and hazardous driving conditions are reported across major airports and highways. The upcoming weekend is also expected to see frigid temperatures and another round of snowstorms, further complicating holiday travel.