Emergency services are responding to a significant incident involving a UPS cargo plane that crashed near Muhammad Ali International Airport in Louisville, Kentucky. Reports indicate that the aircraft caught fire and exploded shortly after takeoff, resulting in injuries among those on board. Authorities have issued a shelter-in-place order for the surrounding area due to the large fire and plumes of smoke visible from miles away. Multiple agencies are on-site to address the situation, and investigation into the cause of the crash is ongoing.