In the aftermath of Hurricane Helene, a significant IV fluid shortage has struck hospitals and dialysis centers across the country. The storm has resulted in the closure of a major manufacturing facility in North Carolina, responsible for 60% of the nation’s IV fluids, due to extensive flooding and damage. Hospitals, including Mass General Brigham, are now rationing supplies and taking measures to conserve fluids as patient safety becomes a growing concern. The largest dialysis solutions facility in the U.S. has also been shuttered, further complicating the already strained medical supply chain. As health systems navigate these challenges, guidance has been issued to ensure continued patient care amidst the shortage.