A UPS cargo plane tragically crashed during takeoff at the Louisville airport, resulting in the deaths of at least 12 individuals, with nine more still unaccounted for. The accident, described as catastrophic, involved the engine detaching from the 34-year-old aircraft, which had recently undergone repairs. Eyewitnesses reported a scene of chaos, with multiple explosions and fires. Investigators are currently working to recover black boxes to determine the cause of the crash, while local officials and the Louisville mayor express deep concern for the missing and the affected community. Additionally, UPS anticipates shipping delays following the incident.