In the wake of the U.S. withdrawal from the World Health Organization (WHO), both New York City and Illinois have taken proactive measures by joining the WHO’s outbreak response and health networks. This move reflects a commitment at the state and city levels to continue combating emerging health threats despite the federal decision. Illinois has specifically joined the Global Outbreak Alert and Response Network (GOARN) to bolster its public health response capabilities. New York City also affirmed its dedication to global health initiatives by joining the UN health network aimed at addressing new pathogens. These actions indicate a clear defiance of the recent federal stance and highlight the importance of local governance in public health.