A UPS cargo plane crashed shortly after taking off from the Louisville Muhammad Ali Airport, resulting in a massive fireball and significant injuries. The incident, which involved a fully fueled MD-11 aircraft with three crew members on board, has resulted in at least three fatalities as reported by officials. A large fire erupted at the scene, prompting a shelter-in-place order for nearby residents as emergency crews responded to control the situation. Live updates and footage of the crash are emerging, detailing the aftermath of this tragic event.