The San Francisco 49ers are dealing with significant injury concerns as both starting quarterback Brock Purdy and tight end George Kittle face uncertain returns. Kittle is expected to miss 3-5 weeks due to a hamstring injury he sustained during the Week 1 game against the Seahawks. Meanwhile, Purdy is struggling with toe and shoulder injuries, leaving his status for the upcoming matchup against the Saints unclear. The team is preparing for a scenario where backup quarterbacks may need to step up as injuries continue to mount for key players.