The San Francisco 49ers have officially ruled out All-Pro tight end George Kittle for their upcoming game against the Los Angeles Rams due to a hamstring injury. Kittle's absence adds to the team's injury woes, as they also face questions about the availability of key players like Nick Bosa and Charvarius Ward. Kittle had been listed as doubtful but was downgraded following a missed practice. This significant injury leaves the 49ers' offense short-handed, impacting their strategy and fantasy football outlook for the week.