The San Francisco 49ers are preparing for their upcoming game against the Chicago Bears while dealing with significant injury concerns. Star defensive end Nick Bosa has been downgraded to out, missing his third consecutive game due to a hip injury. Additionally, tackle Trent Williams has also been ruled out with an ankle issue. In a slight turnaround, safety Talanoa Hufanga has been activated from injured reserve, giving the 49ers a much-needed boost as they navigate through a lengthy injury report affecting several important players. Despite these challenges, the team remains hopeful as they face the Bears with a few roster changes in play.