The San Francisco 49ers are gearing up for their upcoming game against the Seattle Seahawks, but they are facing significant injury concerns. Star tight end George Kittle is reported to be unlikely to play due to a hamstring issue, with sources suggesting a lack of optimism regarding his participation. Additionally, both defensive end Nick Bosa and left tackle Trent Williams are listed as questionable, having missed consecutive practices leading up to the game. 49ers head coach Kyle Shanahan has acknowledged the challenges posed by these injuries, particularly as the team prepares to take on a rival opponent.