A large explosion occurred at a manufacturing plant in the Clifton neighborhood of Louisville, injuring at least 11 employees, with two reported in critical condition. First responders are on the scene, setting up a triage area as reports indicate that several individuals may be trapped under debris. Residents in the vicinity have been urged to shelter in place due to concerns over hazardous materials. The explosion, which collapsed part of the facility, has led to significant damage and ongoing investigations into the cause of the incident.