Recent studies highlight the potential of immunotherapy as a viable alternative to traditional cancer treatments such as surgery and chemotherapy. For certain patients, particularly those with MMRd mutations, immunotherapy has proven effective in treating several cancers while significantly improving quality of life. New findings suggest that immunotherapy could not only spare patients from grueling procedures and harsh therapies but also help prevent cancer recurrence after surgery. This advancement signals a shift in cancer treatment approaches, with the possibility of retaining organs and enhancing overall patient wellbeing.