In a critical matchup against the Miami Dolphins, the San Francisco 49ers will see both Nick Bosa and Dre Greenlaw take the field, despite earlier concerns about their availability. However, the team will be significantly hampered, with running back Isaac Guerendo officially ruled out, leaving them with their fifth-string running back, Patrick Taylor Jr., making his first career start. Head coach Kyle Shanahan acknowledged the challenges posed by the injuries but remains hopeful as the team approaches a crucial point in the season.