Independent directors of 23andMe have resigned en masse, expressing dissatisfaction with CEO Anne Wojcicki's approach to a potential buyout. Despite Wojcicki's commitment to taking the company private, the directors criticized her lack of an actionable proposal and strategic disagreements. Following their resignation, 23andMe's shares dropped significantly, and Wojcicki now indicates she is open to considering third-party takeover proposals. The situation has created uncertainty regarding the company's future direction.