The San Francisco 49ers are grappling with significant injury concerns following their season opener. Star tight end George Kittle has been placed on injured reserve due to a hamstring injury, expected to miss at least four games. Head coach Kyle Shanahan has confirmed that quarterback Brock Purdy is also dealing with multiple injuries, including toe and shoulder issues, making his availability for the upcoming game uncertain. The team is assessing potential replacements for Kittle, and fantasy football players are advised to explore alternatives as the 49ers navigate these early-season injuries.