As the San Francisco 49ers prepare for their Week 13 showdown against the Buffalo Bills, quarterback Brock Purdy is expected to start despite ongoing concerns about his shoulder injury. Head coach Kyle Shanahan has confirmed that Purdy will take the field, although several key players, including left tackle Trent Williams and defensive end Nick Bosa, have been ruled out due to injuries. Purdy, who has been limited in practice, expressed his determination to rely on his competitive nature as he returns to action. Meanwhile, the team is facing significant injury challenges heading into this crucial game.