A series of confirmed cases of brain-eating amoeba (Naegleria fowleri) in South Carolina has led to multiple fatalities, including pediatric patients. The South Carolina Department of Public Health reported that exposures likely occurred at Lake Murray, a popular swimming area. Victims included both adults and children who demonstrated symptoms of this rare but often fatal infection after swimming or potentially coming into contact with contaminated water. Health officials are urging the public to be aware of the risks associated with water activities, especially in freshwater lakes, and are providing guidance on how to prevent exposure to this dangerous organism.