As the Buffalo Bills prepare to host the San Francisco 49ers, a significant lake-effect snowstorm is expected to hit the area, potentially dropping between 3 to 4 feet of snow before game day. With winter weather warnings in place, both teams are gearing up for challenging conditions at Highmark Stadium. The 49ers, coming off a couple of tough losses, will face a refreshed Bills squad returning from their bye week. Key players, including 49ers quarterback Brock Purdy, are set to play, while the Bills may be without tight end Kincaid. Experts highlight the impact of the weather on the game strategy, with both teams needing to adjust to snow and cold wind chills. Fans are advised to prepare for travel disruptions due to road conditions caused by the storm. As excitement builds for the Sunday night matchup, attention focuses on player performances and how the brutal weather will influence the outcome.