Recent studies highlight inspiring cases of individuals who have defied the genetic predisposition to Alzheimer’s disease. Longitudinal analyses reveal that some carriers of dominantly inherited Alzheimer’s mutations have managed to escape the onset of dementia for extended periods. Notably, a former navy mechanic and other patients have successfully avoided showing any symptoms of the disease despite their genetic forecasts. Their experiences challenge longstanding assumptions about the inevitability of Alzheimer’s in genetically vulnerable individuals, suggesting that other factors might play a significant role in determining brain health.