In a significant achievement for American science, Victor Ambros and Gary Ruvkun have been awarded the Nobel Prize in Physiology or Medicine for their pioneering discovery of microRNA and its role in gene regulation. The researchers, both affiliated with institutions in Massachusetts, made groundbreaking contributions that have led to advancements in understanding how microRNA controls the genome, which could have implications for treating diseases such as cancer. Celebrations are underway at their respective universities as the scientific community recognizes the critical nature of their work in the field of molecular biology.