The San Francisco 49ers are dealing with significant injuries to their running back corps, as both Christian McCaffrey and Jordan Mason have been placed on injured reserve following a challenging game against the Bills. Coach Kyle Shanahan confirmed that McCaffrey has suffered a potentially season-ending PCL injury, which is expected to sideline him for at least six weeks. This development raises concerns about the financial implications for the team and their future prospects. With McCaffrey and Mason out, the 49ers will look to rookie Isaac Guerendo to step up in their absence. Ed McCaffrey has also commented on the situation, emphasizing the difficulties his son faces during this tough time.