The 2025 Breakthrough Prize gala honored remarkable contributions in life sciences, fundamental physics, and mathematics, with industry leaders including Rupert Murdoch, Jeff Bezos, and Mark Zuckerberg in attendance. Notable winners, such as Canadian scientist Daniel Drucker, were recognized for their pioneering work on hormones used in anti-obesity drugs like Ozempic and Wegovy. A total of US$3 million was awarded to the scientists who developed these groundbreaking therapies, highlighting the ongoing fight against obesity. The event, described as the ‘Oscars of Science’, showcased the significant advancements made in incretin-based drug research, with multiple Boston-area researchers shining in the spotlight.