Recent studies highlight the effectiveness of vagus nerve stimulation (VNS) as a treatment option for patients suffering from severe depression, particularly those with treatment-resistant cases. Clinical trials, including the RECOVER study from LivaNova, have demonstrated meaningful benefits associated with VNS therapy, despite some mixed results in earlier clinical data. The role of the vagus nerve in mental health continues to be explored, revealing its potential as a significant player in alleviating severe depressive symptoms.