In a significant legal setback, Google has lost its appeal against Epic Games regarding antitrust regulations related to the Play Store. The U.S. Appeals Court upheld the ruling that mandates Google to reform its app store policies and open Android to rival app stores. This decision will allow the Epic Games Store to be available on the Google Play Store and revamp app billing practices, potentially reshaping the Android ecosystem. As a result of this ruling, Google is now required to lift restrictions on app developers, marking a major change in the app marketplace.