In a critical Week 18 matchup, the San Francisco 49ers are set to take on the Arizona Cardinals. George Kittle is active, while major players including Deebo Samuel and Brock Purdy have been ruled out. The 49ers, out of the playoffs, are looking to finish the season on a high note, but they are contending with a lengthy injury list. Coach Kyle Shanahan has provided updates on the statuses of key players, hinting that Samuel might have played his final game with the team. As both teams search for momentum heading into the offseason, the game will feature several backups in starting roles.