The first vaccine advisory meeting under Robert F. Kennedy Jr. is currently underway, following significant delays. The meeting is significant as CDC advisers engage in discussions aimed at refining the usage of COVID-19 booster shots and considering the potential end to universal vaccine recommendations. This review occurs as the CDC seeks to establish narrower vaccine guidance ahead of the 2025–2026 season, marking a pivotal moment for the key vaccine committee as it adapts its recommendations to current public health needs.