The recent shutdown of the federal government has significant implications for scientific research and operations across the United States. Notably, institutions like the NIH are experiencing halted research activities, leading to concerns about the broader impact on the scientific community. Various leaders, including President Hensel and Chairman Babin, have issued statements warning of the risks posed to U.S. science due to this shutdown. Meanwhile, organizations such as APLU have responded with guidance for navigating research expenditures during this uncertain time. The combined effect of these developments could significantly disrupt scientific progress and innovation.