As the San Francisco 49ers prepare for their Monday Night Football game against the Carolina Panthers, both teams are dealing with significant injury challenges. Key players ruled out for the 49ers include edge rusher Tatum Bethune and kicker Eddy Pineiro. The Panthers, on the other hand, will be without three starters, including linebacker Claudin Cherelus and Trevin Wallace, while quarterback Bryce Young is expected to play despite the absences. The 49ers will field a revamped offensive line and are coming off a challenging performance from quarterback Brock Purdy, who struggled with three interceptions in the first half. The injury report continues to develop as both teams finalize their depth charts ahead of the game.