In a significant move towards public health independence, Oregon, California, and Washington have announced the formation of the West Coast Health Alliance aimed at issuing their own vaccine recommendations, separate from the federal guidance provided by the CDC. This collaboration comes as a response to perceived failures and politicization within the CDC, prompting these states to uphold scientific integrity in public health initiatives. Additional states, including Vermont and Connecticut, are considering similar alliances to navigate public health challenges independently from federal authorities. As discussions evolve, New York is also exploring potential changes to its vaccine guidance.