As Week 16 approaches, the San Francisco 49ers and Indianapolis Colts are set for a pivotal Monday Night Football clash, with both teams releasing their preliminary depth charts. The 49ers enter as moderate road favorites, sparking various predictions and betting odds ahead of the game. However, injury updates have raised concerns for the Colts, particularly regarding Ricky Pearsall, who has aggravated a PCL injury, potentially affecting his availability. Despite these uncertainties, both teams are focused on the upcoming matchup, with experts analyzing player stats and making early game predictions. Fans are eager to see key players like Brock Purdy and Alec Pierce in action, as ticket sales continue to rise for this critical encounter.