The San Francisco 49ers will play a regular season game in Mexico City during the 2026 NFL season, marking their return for a second international game. As the designated home team, the 49ers have added this matchup to a challenging schedule that also includes a game in Australia. Fans are already expressing their opinions on the demanding travel commitments, which could see the team covering an unprecedented 38,000 miles during the season. Potential opponents for the game in Mexico City include the Arizona Cardinals and possibly even the Minnesota Vikings. Meanwhile, teams like the Green Bay Packers and Pittsburgh Steelers will not be participating in the Mexico City game.