In a significant reshuffling of U.S. health leadership, Trump has announced the nomination of several key figures, including Johns Hopkins surgeon Marty Makary as the head of the FDA and Fox News contributor Dr. Janette Nesheiwat as Surgeon General. These appointments, along with picks for the CDC, indicate a potential overhaul of health policy, especially in relation to COVID-19 mandates and vaccine positions. Analysts suggest that these nontraditional choices could significantly influence the future direction of public health in the U.S.