As the New England Patriots face off against the San Francisco 49ers in Week 4 of the NFL season, injury reports and key matchups take center stage. The Patriots are struggling with injuries, with three players ruled out, including starting offensive lineman Vederian Lowe, while four others are listed as questionable. The 49ers aim to bounce back from consecutive losses, with analysts predicting crucial performances from their stars like Jauan Jennings and George Kittle. Both teams are looking to turn their fortunes, making this matchup one to watch. The Standard has provided five fast predictions for the game, and fans are eager to see if the 49ers can leverage their home advantage against a Patriots team in turmoil.