As Week 3 of the NFL season approaches, fantasy football players are faced with tough decisions regarding their lineups and potential waiver wire pickups. Key players like Trevor Lawrence and Curtis Samuel are highlighted on the chopping block, while others like Jaleel McLaughlin and various running backs are considered vital waiver wire targets to fill gaps caused by injuries, such as the loss of Isiah Pacheco. The list of available players grows thin as injuries mount, but several viable options remain for managers looking to strengthen their teams. Rankings for quarterbacks, running backs, and wide receivers have been updated to reflect these changes, with particular attention on streaming options like Derek Carr and Sam Darnold. Overall, fantasy owners are urged to prioritize their pickups wisely as they navigate through injuries and performance fluctuations.