As the Buffalo Bills prepare to host the San Francisco 49ers for a highly anticipated Sunday Night Football matchup, fans are bracing for significant weather challenges. Forecasts predict a severe snowstorm that could impact gameplay and even lead to potential postponements. Both teams are coming off their respective bye weeks, with the Bills aiming to solidify their playoff position and the 49ers desperate for a win to avoid postseason elimination. Key players to watch include Bills QB Josh Allen and 49ers edge rusher Leonard Floyd, who will be facing his former team. With severe lake-effect snow expected, spectators are advised to monitor weather updates as kickoff approaches.