Recent studies suggest that COVID-19 mRNA vaccines may significantly enhance cancer treatment efficacy, potentially revolutionizing oncology. Research indicates that these vaccines can sensitize tumors to immune checkpoint blockade and boost the effects of immunotherapy cancer drugs, leading to improved survival rates for patients. Various findings show that COVID-19 vaccines not only spark an immune response that may aid in fighting tumors but also can train the immune system to target cancer cells effectively. Some research reports highlight that cancer patients who received COVID-19 vaccinations experienced up to a five-fold increase in survival, presenting a promising new avenue for cancer therapy.